Modulation of protein biophysical properties by chemical glycosylation: biochemical insights and biomedical implications

Glycosylation constitutes one of the most important posttranslational modifications employed by biological systems to modulate protein biophysical properties. Due to the direct biochemical and biomedical implications of achieving control over protein stability and function by chemical means, there has been great interest in recent years towards the development of chemical strategies for protein glycosylation. Since current knowledge about glycoprotein biophysics has been mainly derived from the study of naturally glycosylated proteins, chemical glycosylation provides novel insights into its mechanistic understanding by affording control over glycosylation parameters. This review presents a survey of the effects that natural and chemical glycosylation have on the fundamental biophysical properties of proteins (structure, dynamics, stability, and function). This is complemented by a mechanistic discussion of how glycans achieve such effects and discussion of the implications of employing chemical glycosylation as a tool to exert control over protein biophysical properties within biochemical and biomedical applications. Received 15 December 2006; received after revision 28 March 2007; accepted 25 April 2007     

Design and passive analysis of a novel softness display device

Simulating the softness property of object is quite a challenge in virtual reality system. A novel softness display system was developed based on the principle of deformable length of elastic element control （DLEEC）. In the system, the equivalent stiffness of the device is adjustable, and is inversely proportional to the third power of the deformable length of elastic beam. PD position control is employed to guarantee the accurate softness display. The softness of the virtual objects in large scale can be felt with the softness display device. Compared with other haptic devices, the device is passive and exert the react force only when the operator ＂actively touch＂ the virtual objects. The stability of the softness display system was analyzed. It was theoretical proved that the system satisfied the criteria of wide impedance range ＂Z-width＂, and the performance was superior to an active system. The experimental results were presented.     

多幅图像显示时色彩压缩的聚类统计算法

在计算机上，同屏显示多幅彩色图像会出现明显的失真（即色彩损失）．特别是两幅图像色调差别较大时（如一幅暖色调，一幅冷色调），失真现象更为严重．为了克服这一缺陷．本文在参考Ｋ均值聚类算法的基础上，优化了初始聚类中心，提出了色彩压缩的聚类统计算法．本算法简单实现较为方便，克服了Ｋ均值算法对色彩压缩不均衡及彩色失真度大的缺点．且不需经过多次迭代即可得到令人满意的效果，压缩时间短．     

高速磁浮曲线地段简支轨道梁墩体系动力响应仿真

应用桥梁动力学、车辆动力学和电磁相互作用原理建立了高速常导磁浮交通车-梁-墩体系动力分析模型,利用数值积分求解了大规模非线性耦合动力方程.在此基础上结合具体线路条件进行了车线耦合动力学检算,得到了曲线地段车辆及梁墩体系动力响应基本规律.该部分的研究为制订合理的高速磁浮线路设计标准提供了理论依据.     

Telomeres and meiosis in health and disease

Telomeres are important segments of chromosomes that protect chromosome ends from nucleolytic degradation and fusion. At meiosis telomeres display an unprecedented behavior which involves their attachment and motility along the nuclear envelope. The movements become restricted to a limited nuclear sector during the so-called bouquet stage, which is widely conserved among species. Recent observations suggest that telomere clustering involves actin and/or microtubules, and is altered in the presence of impaired recombinogenic and chromosome related functions. This review aims to provide an overview of what is currently known about meiotic telomere attachment, dynamics and regulation in synaptic meiosis.     

过程控制中计算机图形信息压缩存贮和图形滚动方法

对工业生产过程控制和管理中的计算机图形显示,提出一种压缩存贮和滚动的新方法。新方法的实施,可使图形数据占用的存贮空间减少约80％,一般地不需使用外存,从而大大提高了显示速度,解决了普通微型机存贮空间和显示速度之间的矛盾,有效地提高了普通微机的功能/价格比。所提出的方法均经工程实践检验过,效果良好。     

Simulation and Experimental Analysis of Super High-Speed Grinding of Ductile Material

This study aims to reduce the work-affected layer of the machined surface by carrying out the grinding at the speed over static pr o pagation speed of plastic wave of ductile materials and also aims to clarify suc h super high-speed machining mechanism.This paper reports on the result obtain ed through the molecular dynamics simulations and experiments on the super-spee d grinding below and beyond static propagation speed of aluminum.From the simul ation results,it is verified that the plastic deformation ...     

Lagrange方程的动力学本质

对广泛应用的Lagrange方程的动力学本质做了探讨,指出在引入速度变换矩阵后,Lagrange方程实际上是牛顿第二定律的一种表示方式;由于引入了速度变换矩阵,Lagrange方程可以方便地在任意的坐标系中建立,对动力学问题的求解提供了一个途径。     

基于FPGA实现的计算机与HDTV显示器测试信号发生器

为产生满足 14种计算机并兼容 4种高清晰度电视 (HDTV)视频标准的 13种测试图案信号,研究开发了计算机与高清晰度电视显示器测试信号发生器.采用现场可编程门阵列(FPGA)完成测试图案数据存储、各种视频标准时序产生及系统控制信号产生等核心功能.利用FPGA的现场可编程功能,采用多个EPROM存储FPGA配置.采用频率发生器技术为多种视频标准提供时钟信号.实践表明,以上方法可行,且成本降低,尺寸从 15cm×21. 5cm减小到11cm×14cm.     

一种混沌神经网络模型及其在优化中的应用

通过在Hopfield神经网络模型 (HNN)中引入非线性自反馈项 ,提出了一种具有暂态混沌动力学行为的神经网络模型。该模型首先经过一个倍周期倒分叉过程进行混沌搜索 ,进而进行类似HNN的梯度搜索。由于它利用了混沌搜索固有的随机性和轨道遍历性 ,因而具有较强的克服陷入局部极小的能力。两个典型的函数优化例子表明了该算法的有效性